Amino-functionalized (meth)acryl polymers by use of a solvent-polarity sensitive protecting group (Br-t-BOC)

• Helmut Ritter,
• Monir Tabatabai and
• Markus Herrmann

Beilstein J. Org. Chem. 2016, 12, 245–252, doi:10.3762/bjoc.12.26

• , IR, GPC and DSC methods. The kinetics of the deprotection step was followed by 1H NMR spectroscopy. The solvent polarity and neighboring group effects on the kinetics of deprotection are discussed. Keywords: amino group protection; bromo-tert-butyloxycarbonyl; deprotection; free radical

Approaches to α-amino acids via rearrangement to electron-deficient nitrogen: Beckmann and Hofmann rearrangements of appropriate carboxyl-protected substrates

• Sosale Chandrasekhar and
• V. Mohana Rao

Beilstein J. Org. Chem. 2012, 8, 1393–1399, doi:10.3762/bjoc.8.161

• amino group is being introduced in umpolung fashion in the strategy described above. Generally, the amino group is introduced nucleophilically, e.g., in the Gabriel method. The trioxaadamantylmethylamine carbamates 10 also represent α-amino acids with both carboxyl and amino group protection. The methyl

Synthesis of highly functionalized β-aminocyclopentanecarboxylate stereoisomers by reductive ring opening reaction of isoxazolines

• Melinda Nonn,
• Loránd Kiss,
• Reijo Sillanpää and
• Ferenc Fülöp

Beilstein J. Org. Chem. 2012, 8, 100–106, doi:10.3762/bjoc.8.10

• reduction of isoxazoline-fused amino ester stereoisomers 2 [48][49] with NaBH4 in the presence of NiCl2 (Scheme 4), which was found to be a suitable reducing system. The reduction carried out by adding NaBH4 to a mixture of NiCl2 and isoxazoline derivative 2 in EtOH/H2O, followed by amino group protection